It is possible to find out using mathematical methods whether a given integer is a prime number or not.
No, 216 221 is not a prime number.
For example, 216 221 can be divided by 463: 216 221 / 463 = 467.
For 216 221 to be a prime number, it would have been required that 216 221 has only two divisors, i.e., itself and 1.
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216 221 is an odd number, because it is not evenly divisible by 2.
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A number is a perfect square (or a square number) if its square root is an integer; that is to say, it is the product of an integer with itself. Here, the square root of 216 221 is about 464.996.
Thus, the square root of 216 221 is not an integer, and therefore 216 221 is not a square number.
The square of a number (here 216 221) is the result of the product of this number (216 221) by itself (i.e., 216 221 × 216 221); the square of 216 221 is sometimes called "raising 216 221 to the power 2", or "216 221 squared".
The square of 216 221 is 46 751 520 841 because 216 221 × 216 221 = 216 2212 = 46 751 520 841.
As a consequence, 216 221 is the square root of 46 751 520 841.
The multiples of 216 221 are all integers evenly divisible by 216 221, that is all numbers such that the remainder of the division by 216 221 is zero. There are infinitely many multiples of 216 221. The smallest multiples of 216 221 are: