Actually, one can immediately see that 222 644 645 cannot be prime, because 5 is one of its divisors: indeed, a number ending with 0 or 5 has necessarily 5 among its divisors.
The last digit of 222 644 645 is 5, so it is divisible by 5 and is therefore not prime.
For 222 644 645 to be a prime number, it would have been required that 222 644 645 has only two divisors, i.e., itself and 1.
A number is a perfect square (or a square number) if its square root is an integer; that is to say, it is the product of an integer with itself. Here, the square root of 222 644 645 is about 14 921.282.